ITB Team Member

Matthias Lütolf

Scientific Director & Lead Multi-tissue Systems Engineering

Matthias is the Scientific Director of the Roche Institute for Translational Bioengineering and a Professor of Bioengineering at the Swiss Federal Institute of Technology in Lausanne (EPFL). His research focuses on the use of cutting-edge bioengineering strategies to guide stem cell-based development to build novel organoids with improved reproducibility and physiological relevance for basic research and real-world applications in drug discovery and development.

List of


  1. M Hofer, MP Lutolf. Engineering organoids. Nature Reviews Materials 6 (5), 402-420 (2021).
  2. G Rossi, N Broguiere, M Miyamoto, A Boni, R Guiet, M Girgin, RG Kelly. Capturing cardiogenesis in gastruloids. Cell stem cell 28 (2), 230-240 (2021).
  3. JA Brassard, M Nikolaev, T Hübscher, M Hofer, MP Lutolf. Recapitulating macro-scale tissue self-organization through organoid bioprinting. Nature Materials 20 (1), 22-29 (2021).
  4. M Nikolaev, O Mitrofanova, N Broguiere, S Geraldo, D Dutta, Y Tabata. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature 585 (7826), 574-578 (2020).
  5. N Brandenberg, S Hoehnel, F Kuttler, K Homicsko, C Ceroni, T Ringel. High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays. Nature biomedical engineering 4 (9), 863-874 (2020).
  6. A Manfrin, Y Tabata, ER Paquet, AR Vuaridel, FR Rivest, F Naef. Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells. Nature methods 16 (7), 640-648 (2019).
  7. JA Brassard, MP Lutolf. Engineering stem cell self-organization to build better organoids. Cell stem cell 24 (6), 860-876 (2019).
  8. G Rossi, A Manfrin, MP Lutolf. Progress and potential in organoid research. Nature Reviews Genetics 19 (11), 671-687 (2018).
  9. L Beccari, N Moris, M Girgin, DA Turner, P Baillie-Johnson, AC Cossy… Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids. Nature 562 (7726), 272-276 (2018).
  10. N Gjorevski, N Sachs, A Manfrin, S Giger, ME Bragina, P Ordóñez-Morán… Designer matrices for intestinal stem cell and organoid culture. Nature 539 (7630), 560-564 (2016).
  11. A Ranga, M Girgin, A Meinhardt, D Eberle, M Caiazzo, EM Tanaka… Neural tube morphogenesis in synthetic 3D microenvironments. Proceedings of the National Academy of Sciences 113 (44), E6831-E6839 (2016).
  12. N Vannini, M Girotra, O Naveiras, G Nikitin, V Campos, S Giger, A Roch, … Specification of haematopoietic stem cell fate via modulation of mitochondrial activity. Nature communications 7 (1), 1-9 (2016).
  13. N Brandenberg, MP Lutolf. In situ patterning of microfluidic networks in 3D cell‐laden hydrogels. Advanced Materials 28 (34), 7450-7456 (2016).
  14. M Caiazzo, Y Okawa, A Ranga, A Piersigilli, Y Tabata, MP Lutolf. Defined three-dimensional microenvironments boost induction of pluripotency. Nature materials 15 (3), 344-352 (2016).
  15. A Ranga, S Gobaa, Y Okawa, K Mosiewicz, A Negro, MP Lutolf. 3D niche microarrays for systems-level analyses of cell fate. Nature communications 5 (1), 1-10 (2014).
  16. KA Mosiewicz, L Kolb, AJ Van Der Vlies, MM Martino, PS Lienemann, … In situ cell manipulation through enzymatic hydrogel photopatterning. Nature materials 12 (11), 1072-1078 (2013).
  17. S Gobaa, S Hoehnel, M Roccio, A Negro, S Kobel, MP Lutolf. Artificial niche microarrays for probing single stem cell fate in high throughput. Nature methods 8 (11), 949-955 (2011).
Full list on Google Scholar